What is a common adverse effect associated with the use of baclofen?

Baclofen, a muscle relaxant commonly used to treat spasticity, is associated with several adverse effects, among which fatigue is notably common. This side effect occurs because baclofen acts as a central nervous system depressant, which can lead to drowsiness and a generalized sense of tiredness. Its mechanism involves inhibiting the release of excitatory neurotransmitters, contributing to reduced muscle spasms but also resulting in sedation and fatigue.

Other potential side effects of baclofen include gastrointestinal disturbances, muscle weakness, and dizziness, but fatigue is particularly relevant and widespread among patients. The prevalence and impact of fatigue often lead healthcare providers to monitor patients closely and advise caution when performing activities that require mental alertness or physical coordination.

Though other side effects such as nausea, skin rash, and weight gain are possible, they are less frequently encountered compared to fatigue, highlighting the importance of awareness around this specific effect when prescribing baclofen. Understanding these potential side effects is crucial for patient management and education, ensuring patients are adequately informed about what to expect during treatment.