What is the relationship between drug distribution and body fat?

The correct choice indicates that more fat decreases drug distribution. This is accurate because the distribution of certain hydrophobic (fat-soluble) drugs can be influenced by the amount of body fat a person has. In individuals with higher body fat percentages, these drugs can become sequestered in adipose tissue, leading to a lower concentration of the drug in the bloodstream. Consequently, the effectiveness of the drug may be reduced, and dosing may need to be adjusted to achieve the desired therapeutic effect.

Higher body fat increasing drug distribution typically applies to lipophilic drugs that are absorbed and stored in fat tissues. However, while they may distribute into fat, the presence of excess adipose tissue can slow the release of the drug back into circulation, which can diminish effective drug levels in other tissues.

The assertion that body fat does not impact drug distribution overlooks the significant role that fat solubility plays in the pharmacokinetics of many drugs. Lastly, while drug type certainly affects distribution, it is not the sole factor. Other characteristics, including body composition such as fat percentage, also play a critical role in how drugs are distributed throughout the body.