What medication can interact with IV calcium gluconate?

Calcium gluconate is often used to treat hypocalcemia or for other indications such as managing hyperkalemia. One significant interaction to be aware of is with digoxin, a medication commonly used to treat heart failure and certain types of arrhythmias. When calcium gluconate is administered along with digoxin, it can increase the risk of digoxin toxicity. This occurs because calcium can enhance the effects of digoxin on the heart, leading to an increased risk of arrhythmias. Monitoring of digoxin levels and cardiac rhythm is prudent when these medications are used together to prevent serious side effects.

The other medications listed do not have the same significant risk of interaction with calcium gluconate. For example, felodipine is a calcium channel blocker, and while it may have some interaction with calcium levels, it does not present the same acute risk of toxicity as digoxin. Guaifenesin is an expectorant with a different mechanism of action and does not interact pharmacologically with calcium gluconate. Regular insulin has its own set of interactions based on glucose metabolism but does not pose a direct risk when combined with calcium gluconate. Thus, digoxin is the medication of concern when considering interactions with IV calcium glucon